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Martin Sweeney Darren Conboy Styliana I. Mirallai Fawaz Aldabbagh 《Molecules (Basel, Switzerland)》2021,26(9)
This review article provides a perspective on the synthesis of alicyclic and heterocyclic ring-fused benzimidazoles, imidazo[4,5-f]benzimidazoles, and imidazo[5,4-f]benzimidazoles. These heterocycles have a plethora of biological activities with the iminoquinone and quinone derivatives displaying potent bioreductive antitumor activity. Synthesis is categorized according to the cyclization reaction and mechanisms are detailed. Nitrobenzene reduction, cyclization of aryl amidines, lactams and isothiocyanates are described. Protocols include condensation, cross-dehydrogenative coupling with transition metal catalysis, annulation onto benzimidazole, often using CuI-catalysis, and radical cyclization with homolytic aromatic substitution. Many oxidative transformations are under metal-free conditions, including using thermal, photochemical, and electrochemical methods. Syntheses of diazole analogues of mitomycin C derivatives are described. Traditional oxidations of o-(cycloamino)anilines using peroxides in acid via the t-amino effect remain popular. 相似文献
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Recyclable and reusable Pd(OAc)2/PPh3/PEG‐2000 system for homocoupling reaction of arylboronic acids under air without base 下载免费PDF全文
A stable and efficient Pd(OAc)2/PPh3/PEG‐2000 catalytic system for homocoupling of arylboronic acids has been developed. In the presence of Pd(OAc)2 and PPh3, the homocoupling reaction of arylboronic acids was carried out smoothly in PEG‐2000 at 70 °C under air without base to afford a variety of symmetric biaryls in good to excellent yields. The isolation of the products was readily performed by extraction with diethyl ether, and the Pd(OAc)2/PPh3/PEG‐2000 system could be easily recycled and reused six times without significant loss of catalytic activity. Copyright © 2014 John Wiley & Sons, Ltd. 相似文献
86.
Pankaj Kumar Chaurasia Sudha Yadava Shashi Lata Bharati Sunil Kumar Singh 《Green Chemistry Letters and Reviews》2014,7(1):100-104
This communication reports the selective bioconversions of substituted toluenes to substituted benzaldehydes without the help of any mediators by purified laccase of indigenous fungal strain Fomes durissimus microbial type culture collection (MTCC)-1173. Molecular mass of laccase purified by sodium dodecyl sulfate-polyacrylamide gel electrophoresis was found to be 74.86 kDa (~75 kDa). By using this purified laccase, selective bioconversions of 3-nitrotoluene to 3-nitrobenzaldehyde, 2-fluorotoluene to 2-fluorobenzaldehyde, 4-fluorotoluene to 4-fluorobenzaldehyde, 2-chlorotoluene to 2-chlorobenzaldehyde and 4-chlorotoluene to 4-chlorobenzaldehyde have been done without the help of mediator molecules within 1–2 hrs at room temperature and pressure with high yields (>90%). All the above bioconversions are good examples of green chemistry. 相似文献
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A simple “green synthesis” of noble metal nanoparticles by direct reaction between Dextran‐graft‐lactone copolymers and metal salts without the need to separately add reducing and stabilizing agents was carried out. The effects of the composition, molecular weights of copolymers and solvents on the characteristics of the nanoparticles were considered. The amphiphilic character of the copolymers seems to be an important factor in the results of the synthesis. According to the results, general correlations between experimental parameters of synthesis and characteristics of the obtained nanoparticles were established. Techniques such as, transmission electron microscopy, scanning electron microscopy, UV–visible spectroscopy, Zeta Potential, dynamic light scattering and Fourier transform Infrared Spectroscopy, were used for the characterization of the products. The results indicate the possibility of control of the characteristics of the nanostructured material. Copyright © 2014 John Wiley & Sons, Ltd. 相似文献
88.
Immobilization of metal ions onto inorganic supports has very interesting biological, industrial, and catalysis applications. In this study, CoFe2O4@SiO2@PUF@Zn(OAc)2 nanostructure was successfully fabricated by immobilization of zinc acetate on the surface of poly(urea-formaldehyde) supported on magnetic CoFe2O4@SiO2 nanoparticles through a layer-by-layer assembly. The structure of hybrid nanoparticles was characterized by Fourier transform infrared spectroscopy, X-ray diffraction, thermogravimetric analysis, energy-dispersive X-ray spectroscopy, inductively coupled plasma atomic emission spectroscopy, vibrating sample magnetometry, Brunauer–Emmett–Teller surface area analysis, scanning electron microscopy, and transmission electron microscopy. Zinc-poly(urea-formaldehyde) supported on magnetic nanoparticles (MNPs@SiO2@PUF@Zn) was successfully used for the synthesis of spirooxindolopyran and spirooxindoloxanthene derivatives in aqueous medium as an environmentally benign condition. High yields, short reaction times, green solvent, reusability without significant reduction in catalytic activity, and simple separation of the catalyst using an external magnet along with environmental compatibility are some benefits of this procedure. 相似文献
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Aicha Mhamdi 《Green Chemistry Letters and Reviews》2018,11(1):12-17
A green and versatile method for the preparation of γ-hydroxyphosphonate and phosphine oxide derivatives in 5?min, is accomplished through the reduction of γ-phosphonylketones with sodium borohydride supported on alumina, at room temperature, under solvent free conditions. 相似文献
90.
Hebatallah M. Essam Martin N. Saad Eman S. Elzanfaly Sawsan M. Amer 《Biomedical chromatography : BMC》2020,34(11):e4941
A sensitive micellar electrokinetic chromatography method is presented to simultaneously quantify ofloxacin, gatifloxacin, dexamethasone sodium phosphate and prednisolone acetate. The method has the advantages of being rapid, accurate, reproducible, ecologically acceptable and sensitive. The electrophoretic separation utilized 20 mm borate buffer as background electrolyte with pH 10.0 ± 0.1 and 50 mm sodium dodecyl sulfate as a micelle forming molecule. A capillary tube (50 μm i.d., 33 cm) of fused silica was used and on-column diode array detection at 243 nm for dexamethasone sodium phosphate and prednisolone acetate, and 290 nm for ofloxacin and gatifloxacin. Various factors were optimized such as the background electrolyte (type, concentration and pH), addition of sodium dodecyl sulfate and its concentration, detection wavelength, applied voltage and injection parameters. The studied drugs were efficiently separated in 6.2 min, at 20 kV with high resolution. The greenness of the method was estimated using an eco-scale tool and the presented method was found to have excellent green characteristics. The method was validated in conformance with International Conference on Harmonization guidelines, with acceptable accuracy, precision and selectivity. The suggested method can be employed for the economic analysis of the four drugs in dissimilar binary combinations of eye drops saving solvents and chemicals. 相似文献